Dietary composition alters gentamicin-induced nephrotoxicity in rats
نویسندگان
چکیده
منابع مشابه
Protective effect of crocin on gentamicin-induced nephrotoxicity in rats
Objective(s): Gentamicin is used for the treatment of Gram-negative bacterial infections. However, gentamicin administration is limited because of nephrotoxicity. The aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. Materials and Methods: Thirty two male Wistar rats received gentamicin (100 mg/kg, IP), with or without c...
متن کاملEffect of normobaric hyperoxia on gentamicin-induced nephrotoxicity in rats
Objective(s):Gentamicin sulphate (GS) nephrotoxicity seems to be related to the generation of reactive oxygen species. There is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. Materials and Methods: Forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily GS, groups 3,4 and 5 received oxygen 2 hr/day...
متن کاملBiochemical effects of oleuropein in gentamicin-induced nephrotoxicity in rats
BACKGROUND Oleuropein is a natural antioxidant and scavenging free radicals. In the present study, we examined effect of oleuropein on the paraoxonase 1 (PON1) activity, lipid peroxidation, lipid profile, atherogenic indexes, and relationship of PON1 activity by high-density lipoprotein-cholesterol (HDL-C) and atherogenic indices in gentamicin (GM)-induced nephrotoxicity in rats. METHODS This...
متن کاملEffect of normobaric hyperoxia on gentamicin-induced nephrotoxicity in rats
OBJECTIVES Gentamicin sulphate (GS) nephrotoxicity seems to be related to the generation of reactive oxygen species. There is evidence that oxygen preconditioning increases the activity of antioxidant enzymes. MATERIALS AND METHODS Forty eight female rats were divided into 6 groups (n=8) as follows: group 1 was the control, group 2 received daily GS, groups 3,4 and 5 received oxygen 2 hr/day ...
متن کاملProtective effect of crocin on gentamicin-induced nephrotoxicity in rats
OBJECTIVES Gentamicin is used for the treatment of Gram-negative bacterial infections. However, gentamicin administration is limited because of nephrotoxicity. The aim of the present study was to evaluate the protective effect of crocin against gentamicin-induced nephrotoxicity in rats. MATERIALS AND METHODS Thirty two male Wistar rats received gentamicin (100 mg/kg, IP), with or without croc...
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ژورنال
عنوان ژورنال: Physiology & Behavior
سال: 2002
ISSN: 0031-9384
DOI: 10.1016/s0031-9384(02)00848-x